Archives
- June 2013 (3)
- May 2013 (2)
- April 2013 (12)
- March 2013 (1)
- February 2013 (10)
- January 2013 (5)
- December 2012 (2)
- November 2012 (14)
- October 2012 (11)
- September 2012 (5)
- August 2012 (7)
Authors
Sections
- Experiments (72)
Tools
Show/Hide Keys
Formation of a sulfonate as an alternative to the sulfonamides (MD 29-1)
Reaction start time: 7:30 PM EST, 9/5/13
MD 27-5 (65 mg, 0.23 mmol, 1 equiv.) was dissolved in pyridine (5 mL). Methyl glycolate (102 mg, 1.1 mmol, 4.9 equiv.) was added and the reaction stirred overnight.
NMR:
MD 32-1.pdf
MD_32-1.rar
Attached Files
Formation of sulfonyl chloride intermediate to be used to form a sulfonamide
Reaction start time: 1:30 PM EST, 8/5/13
MD 6-7 (0.11 g, 0.18 mmol, 1 equiv.) was stirred in dry DCM (3 mL) followed by addition of dry DMF (14 uL, 0.18 mmol, 1 equiv.). Dropwise oxalyl chloride (0.14 mL, 1.6 mmol, 8 equiv.). The reaction mixture was stirred at room temperature for 3 hours.
Risk and Hazard assessment:
Chlorination of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate using oxalyl chloride (MD 27-1)