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8th May 2013 @ 04:22
Formation of sulfonyl chloride intermediate to be used to form a sulfonamide   Reaction start time: 1:30 PM EST, 8/5/13 MD 6-7 (0.11 g, 0.18 mmol, 1 equiv.) was stirred in dry DCM (3 mL) followed by addition of dry DMF (14 uL, 0.18 mmol, 1 equiv.). Dropwise oxalyl chloride (0.14 mL, 1.6 mmol, 8 equiv.). The reaction mixture was stirred at room temperature for 3 hours.   Risk and Hazard assessment:Chlorination of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate using oxalyl chloride (MD 27-1)