All Notebooks | Help | Support | About
4th April 2013 @ 06:28

Methyl ester sulfonamide was obtained in 27% yield. Product was used in MD-30.

===


Formation of methyl ester sulfonamide as a step towards forming 2-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonamido)acetate, a possible antimalarial.

Reaction start time: 10:30 AM EST 26/3/13

Crude MD 27-4 (0.11 g, 0.30 mmol, 1 equiv.) was dissolved in pyridine (10 ml) and mixed with Glycine methyl ester (0.13 g, 10 mmol, 3.3 eq.), which was was stirred overnight at room temperature. The reaction was then concentrated under reduced pressure to give the crude product which was columned with 50:50, ethyl acetate:hexane solvent mixture to give the purified product (30 mg 0.080 mmol, 27% yield).

 

Risk and hazard assessment:

Same as second half of Synthesis of 2-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonamido)acetamide (MD 26-2)

Attached Files
MD 29-1.png