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4th April 2013 @ 06:27

Reaction start time: 5:00 PM EST, 25/3/13

MD 6-6 (0.12 g, 0.20 mmol, 1 equiv.) was stirred in dry DCM (3 mL) followed by addition of dry DMF (15 uL, 0.20 mmol, 1 equiv.). Dropwise oxalyl chloride (0.14 mL, 1.6 mmol, 8 equiv.). The reaction mixture was stirred at room temperature under Argon overnight.

DCM (20 mL) and water (20 mL) was added to the reaction, the organic layer was dried and concentrated to give a brown grainy oil (0.13 mg). Which was used with no further purification.

Risk and Hazard assessment:
Chlorination of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate using oxalyl chloride (MD 27-1)