All Notebooks | Help | Support | About
4th April 2013 @ 06:05

Reaction start time: 2:00 PM EST 9/3/13

Crude MD 28-1 was dissolved in pyridine (10 ml) and mixed with Glycinamide hydrochloride (0.13 g, 0.10 mmol, 5 eq.), which was was stirred overnight at room temperature. The reaction was then concentrated under reduced pressure to give the crude product (50 mg). The crude product was columned with 50:50, ethyl acetate:hexane solvent mixture to give the purified product (20 mg).

 

Risk and hazard assessment:

Same as second half of Synthesis of 2-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonamido)acetamide (MD 26-2)

Attached Files
MD 28-1.png