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18th February 2013 @ 03:15

Isolation of unknown product from the reaction in MD 12-5.

Reaction time: 12:00 PM EST, 11/2/13

MD 6-5 (100 mg, 0.34 mmol, 1 equiv.) was stirred in DMSO (5 mL) followed by addition of thionyl chloride, (200 µL, 0.34 mmol, 1 equiv.) reaction was stirred at room temperature for 2 hours. Water (20 mL) and Ethyl Acetate (20 mL) were added to the reaction.

See also: Synthesis of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate (MD 6-5)

Synthesis of N-benzyl-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonamide (MD 12-4)

Risk and hazard assessment: Same as first step of Synthesis of N-benzyl-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonamide (MD 12-2)

Attached Files
MD 12-2.png