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Sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate was synthesised (1.38 g, 47% yield) to be used in sulfonamide formation.
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Synthesis of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate with reduced sulfur trioxide pyridine complex.
Reaction start time: 12:30 AM EST 30/1/13
AEW 1-1 (2.0 g, 10 mmol, 1 equiv. ) and Sulfur trioxide pyridine (1.71 g, 10 mmol, 1 equiv.) were refluxed in toluene (16 mL) for 16 hours. Reaction was concentrated under reduced atmosphere followed by addition of water and heating to 100° C, the boiling reaction was then neutralised with sodium carbonate (approx. 1 g). Water was then removed under reduced pressure. A 90:10 ethanol:water mix (20 mL) was added to the residue and the solution heated to 90° C then filtered. The product was then concentrated to give the final product (1.38 g 4.7 mmol, 47% yield).
See also: Method used from this paper Synthesis of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate (MD 6-1) Synthesis of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate (MD 6-2)
Risk and Hazard assessment: Same as Synthesis of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate (MD 6-1)
- Synthesis of N-benzyl-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonamide (MD 12-5)
- Investigation of the chlorination of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate with thionyl chloride at 0°C (MD 25-1)
- NMR investigation of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate chlorination using phosphorous pentachloride (MD 15-2)
- Chlorination of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate (MD 15-3)
Uri:https://malaria.ourexperiment.org/uri/25e
Key:97f68cf20bfef1e3ab2f8d3393755d81
Last Updated:8th February 2013 @ 01:28