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31st January 2013 @ 15:29

Reaction start time: 12:00 AM EST 17/1/13

MD 1-2 (5.2 g, 22 mmol) was dissolved in EtOH (10 mL). 20% NaOH(aq) (32 mL) was added to the solution. Reaction was heated to 90°C and left over night. 11:30 AM TLC showed reaction had completed.

5 M HCL (10 mL) was used to acidify the solution so that light brown crystals formed. The crystals were filtered and washed with H2O (40 mL) and EtOH (20 mL) then concentrated under reduced atmosphere to give the final product (3.7 g, 15 mmol, 68% yield).

See also:Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (PMY 8-2) Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (PMY 8-4) Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (JRC 2-1)

Risk and Hazard assessment: Same as Hyrdolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (MD 2-1)

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