Grad Dip Arylpyrrole

Reaction start time: 12:00 AM EST 17/1/13

MD 1-2 (5.2 g, 22 mmol) was dissolved in EtOH (10 mL). 20% NaOH(aq) (32 mL) was added to the solution. Reaction was heated to 90°C and left over night. 11:30 AM TLC showed reaction had completed.

5 M HCL (10 mL) was used to acidify the solution so that light brown crystals formed. The crystals were filtered and washed with H₂O (40 mL) and EtOH (20 mL) then concentrated under reduced atmosphere to give the final product (3.7 g, 15 mmol, 68% yield).

See also:Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (PMY 8-2) Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (PMY 8-4) Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (JRC 2-1)

Risk and Hazard assessment: Same as Hyrdolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (MD 2-1)