All Notebooks | Help | Support | About
29th November 2012 @ 23:45
Upscaled synthesis of 1-ethoxy-1-oxopropan-2-yl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate through formation of ester bond between 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylic acid and ethyl 2-bromopropanoate.

4123.png

Reaction start time: 5:20 PM EST 28/11/12
MRN 57-1 (1.0 g, was dissolved in DMF (20 mL), then Potassium Carbonate (1.5 g) was added after. The mixture was stirred at room temperature for 20 minutes, followed by addition of Ethyl-2-bromopropionate (0.76 mL, ) and was left stirring overnight at room temperature.

At 12:00 PM ethyl acetate:water (60 mL, 1:1) mixture was added to the reaction and extracted with ethyl acetate (3 × 20 mL) the organic layers were combined, washed with water (20 mL), brine (20 mL), then dried over magnesium sulfate and concentrated to a brown oil, which was left to dry under high vac for 5 hours.

Risk and Hazard assessment:
Same as Upscaled synthesis of 1-ethoxy-1-oxopropan-2-yl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (MD 17-2).
Linked Posts
This post is linked by: