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23rd November 2012 @ 02:25
Synthesis of 2-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carbonyl)oxy)propanoic acid


Reaction start time: 5:32 PM EST 22/11/12
MRN 57-1 (0.23 g, 1 mmol,) was dissolved in DMF (6 mL), potassium carbonate (0.5 g,) was added and the mixture was stirred for 30 minutes at room temperature after which 2-bromopropionic acid (120 ┬ÁL, 1.3 mmol,), TLC at 8 PM showed the presence of starting material.

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Risk and Hazard assessment:
Same as Synthesis of 1-ethoxy-1-oxopropan-2-yl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate through ester synthesis (MD 17-1),exception is 2-bromopropionic acid is corrosive and causes severe burns.
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