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14th November 2012 @ 22:49
Upscaled synthesis of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate.

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Reaction start time: 3:00 PM EST 8/11/12
Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1Hpyrrole (1.0 g, 5.3 mmol, 1 equiv) and Sulfur trioxide pyridine (0.8 g, 5.3 mmol, 1 equiv) were refluxed in toluene (8 mL) for 16 hours.

See also:
Method used from this paper
Synthesis of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate (MD 6-1)
Synthesis of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate (MD 6-2)

Risk and Hazard assessment:
Same as MD 6-3 Upscaled synthesis of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate (MD 6-3) except increased amounts of starting material.