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2nd November 2012 @ 03:15
Investigation of the chlorination of sodium 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonate using NMR.


Reaction start time: 8:30 AM EST 2/11/12
MD 6-3 was mixed with CDCL3 in an NMR tube, 1HNMR spectra recorded. Thionyl chloride (2 ┬ÁL, 0.01 mmol) and 1HNMR spectra was recorded continuously for 25 minutes. 1.5 hours later another spectra was taken.

MD 6-3 would not dissolve in CDCL3. When Thionyl Chloride was added MD 6-3 dissolved in CDCL3.

See also:

Risk and Hazard assessment:
Same as MD 12-1: Synthesis of N-benzyl-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonamide (MD 12-1)
Attached Files
MD 13-1.png