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22nd January 2017 @ 20:18
The aim of this experiment is to produce (E)-2-chloro-6-(2-(2-(piperidin-1-yl)benzylidene)hydrazineyl)pyrazine via condensation1 of 2-chloro-6-hydrazinylpyrazine and 2-Piperidinylbenzaldehyde.   Figure 1: Reaction to produce (E)-2-chloro-6-(2-(2-(piperidin-1-yl)benzylidene)hydrazineyl)pyrazine This reaction was carried out as a trial on a small scale, to reduce wastage of the aldehyde synthesised in the previous step. Table 1: Table of Reagents used in experiment. Reagent Equivalents Moles (mmol) Quantities 2-chloro-6-hydrazinylpyrazine   1 0.264 381 mg 2-Piperidinylbenzaldehyde   1 0.264 500 mg Ethanol   - - ~2.5 mL Procedure  To a stirred solution of Ethanol (2.5 mL), 2-chloro-6-hydrazinylpyrazine (381 mg, 0.264 mmol) was added in a flask. 2-Piperidinylbenzaldehyde (500 mg, 0.264 mmol) was then added. The solution was left to stir for 5 hours. The resulting mixture was burnt orange in colour. TLC analysis was undertaken (EtOAc/Pet. Ether 1:1) which showed that a new product had formed. 1H NMR of the product was taken, which showed inconclusive results   Figure 2: NMR of product obtained. References Synthesis of (E)-2-chloro-6-(2-(naphthalen-2-ylmethylene)hydrazinyl)pyrazine (TY 2-1), http://malaria.ourexperiment.org, (accessed November 2016)