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09-06-2016, First step in synthesis of the hetero-oxadiazole, reaction of 2-6 dichloropyrazine with malononitrile, following procedure from Nikishkin et al (2013)
09-11-2016, Work up of the second attempt at step 1
09-23-2016. Step 1 redo, on 5 gram scale
09-24-2016. Work up of 09-23-2016
09-29-2016, work up and purification of [4]
09/28/2016 Step 4, on a larger scale this time. Conversion of methyl 6-chloropyrazine-2-carboxylate [3] to methyl 6-hydrazineylpyrazine-2-carboxylate [4] using hydrazine according to AEW 85-5
10/07/2016 GC mass spec characterization of rxn from [4]->[5]
10/18/16: Trial work up of reaction of 6-chloropyrazinecarbonitrile and hydrazine
10/4/16: Trial of Step 4:Product [4] to Product [5]
10/6/16: Trial Synthesis of 6-hydrazinelypyrazine-2-carbonitrile and from 6- hydrazinelypyrazine-2-carboximidhydrazide from chloropyrazinecarbonitrile
9/12/16 Step 2 in synthesis. Going from [2]->[3]
9/13/16: Work-up of product [3] and TLC plates
9/15/16: Second Synthesis of Methyl 6-chloropyrazine-2-carboxylate [product 3]
9/18/16-9/20/16: Trial Synthesis of Methyl 6-hydrazineylpyrazine-2-carboxylate (Product 4)
9/22/16: Inconclusive Trial Synthesis of Methyl 6-hydrazineylpyrazine-2-carboxylate (Product 4)
9/25/16-9/27/16: Synthesis of Product 3, methyl 6-chloropyrazine-2-carboxylate
9/27/2016 Late Night
9/29/2016 HNMR of product 4, and HNMR of product 4 after D2O exchange 01/10/2016
9/8/16-Continued Synthesis of 2-(6-chloropyrazin-2(1H)-ylidene)malononitrile
CNMR so far
HNMR so far, of all relevant compounds
The Synthetic scheme of Hetero-oxadiazole Synthesis
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15th September 2016 @ 04:24

Like the previous step, we are following the procedure outlined in Our goal is to go from compound [2] to [3]. See attached image.

Dissolved 0.3471 g 4.47 mmol of [2], which was purified previously, in 47 mL MeOH and stirred under argon. Next, 6.71 mmol, 0.4963 g of Li2CO3 was added slowly, and an immediate color change in the stirring solution was observed, from opaque red through opaque peach to opaque yellow. After stirring for 30 minutes under argon, the solution was placed in an ice bath. Then, 2.069 g, 3.35 mmol of magnesium monoperoxuphthalate (MMPP) (~80% tech) was added and the solution slowly became white as it stirred.
Unlike in Nikishkin et al, we left it stirring overnight, not just for 3 hours. 




Nikishkin, Nicolai I. et al. "Pyrazine-Functionalized Calix[4]Arenes: Synthesis By Palladium-Catalyzed Cross-Coupling With Phosphorus Pronucleophiles And Metal Ion Extraction Properties". New J. Chem. 37.2 (2013): 391-402. Web. 4 Sept. 2016. .

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