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Biological evaluation of OSM-E-1 through 3 performed at the Dundee Drug Discovery Unit by Irene Hallyburton.
Unfortunately all three compounds tested were inactive, possibly with activity ~60,000 nM for OSM-E-2 although this may be an artifact of the fitting.
OSM-E-1 through OSM-E-3 - corrected protocol.pdf
Synthetic procedures:
OSM-E-1: Amidation of PT-1-9A (PT-1-10)
OSM-E-2: Amidation of PT-1-11 (PT-1-12)
OSM-E-3: amidation of PT-1-3C (PT-1-5)
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