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9th May 2013 @ 12:44

Biological evaluation of OSM-E-1 through 3 performed at the Dundee Drug Discovery Unit by Irene Hallyburton.

Unfortunately all three compounds tested were inactive, possibly with activity ~60,000 nM for OSM-E-2 although this may be an artifact of the fitting.

 

 

OSM-E-1 through OSM-E-3 - corrected protocol.pdf

 

Synthetic procedures: 

OSM-E-1: Amidation of PT-1-9A (PT-1-10)

OSM-E-2: Amidation of PT-1-11 (PT-1-12)

OSM-E-3: amidation of PT-1-3C (PT-1-5)

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