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Show/Hide Keys
Biological evaluation of OSM-S-117 through 138 (also OSM-S-107) performed in Vicky Avery's lab by Sabine Fletcher.
Data for previous OSM-S compounds can be found here - OSM Compound List
Unfortunately only two (OSM-S- 137 and 138) were active on 3D7.
The summary also contains information about the solubility: several of the compounds turned opaque when diluted down to 4% DMSO, which suggests poor solubility in this condition. I made sure to mix the compounds very well before the final 1:10 dilution step in the assay plate.
One compound (OSM-S-134) did not dissolve well in 100% DMSO. It still contained many needle-like crystals after shaking over night, which means that we do not know the actual concentration of the dissolved compound in the assay. As tested here, it was completely inactive.
Click for larger image
Click for larger image
Depictions of Data including cLogP values and comments on solubility:
Activities of hit vs simple analogs
Variation of amine to morpholine
Variation in amine component
Comparison with known other TCMDC hits