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15th May 2012 @ 00:53
Biological testing of the 2nd round of compounds reported on 05/05/12 by James S. Pham from the University of Melbourne. Visual summary of results and compound structures: [data]2383[/data] [b]Methods Overview:[/b] "Compounds were tested for inhibition of Plasmodium falciparum growth using a SYBR green I fluorescence based assay. Dose response curves were generated comprising of 8 points using a 2-fold serial dilution for the maximum final concentration of 1000 nM. The lowest concentration tested was 7.81 nM." [url=https://docs.google.com/spreadsheet/ccc?key=0AjjLI6V9UglkdE95SHlwMmRFTU5TX3M4bWRwWTdGOWc]Raw Data[/url] originally posted on [url=https://plus.google.com/u/0/101939803104123532645/posts/EqkqwCvP3z5]Google+[/url] along with a [url=https://docs.google.com/document/d/1ErYmzEruRmTzUhWZaepAoK1DHBt9AM4wHLlcxJ4JqPw/edit]detailed method[/url] description and report. Raw data and graphs in excel format: [data]2381[/data] Compounds tested: PMY 12-5, PMY 27-2, PMY 31-5, PMY 34-1, ZYH 3-1, ZYH 5-1, ZYH 6-1/6-2, ZYH 7-2, ZYH 10-2 A, ZYH 10-2 B, ZYH 12-1/12-2, ZYH 15-1, ZYH 16-1, ZYH 17-1, ZYH 18-1, ZYH 19-1, ZYH 22-3, ZYH 23-1 Analysis of the same compounds: [blog]2722[/blog] [blog]2430[/blog] Results largely consistent with above analyses.
Attached Files
Raw Data and Graphs
Visual Summary