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28th November 2017 @ 01:00

A set of 26 Series 4 Triazolopyrazine compounds were sent to have their efficacy evaluated against Plasmodium flaciparum in-vitro at Dundee (GitHub issue #8)

The data has been posted here

Strings:

MMV Number SMILES InChI InChI Key
MMV1576784 FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC/C4=C/BBBBBBBBBB4)N32 InChI=1S/C16H22B10F2N4O2/c27-16(28)34-12-3-1-10(2-4-12)15-31-30-13-8-29-9-14(32(13)15)33-6-5-11-7-17-19-21-23-25-26-24-22-20-18-11/h1-4,7-9,16-26H,5-6H2/b11-7- AGPVLTOPROUGPQ-XFFZJAGNSA-N
MMV1576785 FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC(N4CCOCC4)C5=CC=CC=C5)N32 InChI=1S/C24H23F2N5O3/c25-24(26)34-19-8-6-18(7-9-19)23-29-28-21-14-27-15-22(31(21)23)33-16-20(17-4-2-1-3-5-17)30-10-12-32-13-11-30/h1-9,14-15,20,24H,10-13,16H2 NLNZVWQRJHUCOA-UHFFFAOYSA-N
MMV1576786 FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCCN4CC5(COC5)C4)N32 InChI=1S/C19H19F2N5O3/c20-18(21)29-14-3-1-13(2-4-14)17-24-23-15-7-22-8-16(26(15)17)28-6-5-25-9-19(10-25)11-27-12-19/h1-4,7-8,18H,5-6,9-12H2 CWOUGAWUCYKRFC-UHFFFAOYSA-N
MMV1576787 FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC4=CC=C(CO)C=C4)N32 InChI=1S/C20H16F2N4O3/c21-20(22)29-16-7-5-15(6-8-16)19-25-24-17-9-23-10-18(26(17)19)28-12-14-3-1-13(11-27)2-4-14/h1-10,20,27H,11-12H2 VIQWBWLDUDXSBJ-UHFFFAOYSA-N
MMV1576788 FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCCC4COC4)N32 InChI=1S/C17H16F2N4O3/c18-17(19)26-13-3-1-12(2-4-13)16-22-21-14-7-20-8-15(23(14)16)25-6-5-11-9-24-10-11/h1-4,7-8,11,17H,5-6,9-10H2 VMXSRABLXQMXLK-UHFFFAOYSA-N
MMV1576789 FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC4(OCCO4)C5=CC(F)=C(F)C=C5)N32 InChI=1S/C22H16F4N4O4/c23-16-6-3-14(9-17(16)24)22(32-7-8-33-22)12-31-19-11-27-10-18-28-29-20(30(18)19)13-1-4-15(5-2-13)34-21(25)26/h1-6,9-11,21H,7-8,12H2 UAZNIGDYRZOARG-UHFFFAOYSA-N
MMV1576790 FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC/C4=C/BBBBB[BH]5[BH]([H]5)BB4)N32.[Cs+] InChI=1S/C16H22B9F2N4O2.Cs/c26-16(27)33-12-3-1-10(2-4-12)15-30-29-13-8-28-9-14(31(13)15)32-6-5-11-7-17-19-20-21-23-25-24(34-25)22-18-11;/h1-4,7-9,16-25H,5-6H2;/q;+1/b11-7-; GZUNPULXOLJYSG-AJULUCINSA-N
MMV1576791 FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC(N(CC)CC)C4=CC(F)=C(F)C=C4)N32 InChI=1S/C24H23F4N5O2/c1-3-32(4-2)20(16-7-10-18(25)19(26)11-16)14-34-22-13-29-12-21-30-31-23(33(21)22)15-5-8-17(9-6-15)35-24(27)28/h5-13,20,24H,3-4,14H2,1-2H3 FFKUJTSUMDVIQH-UHFFFAOYSA-N
MMV1576792 FC(F)OC(C=C1)=CC=C1C2=NN=C3C=NC=C(OCC(N(CC)C)C4=CC(F)=C(F)C=C4)N32 InChI=1S/C23H21F4N5O2/c1-3-31(2)19(15-6-9-17(24)18(25)10-15)13-33-21-12-28-11-20-29-30-22(32(20)21)14-4-7-16(8-5-14)34-23(26)27/h4-12,19,23H,3,13H2,1-2H3 XPBTWBXREHLVRP-UHFFFAOYSA-N
MMV1576793 FC1=CC(CCOC2=CN=CC3=NN=C(C4=CC=C(C(N)=O)C=C4)N32)=CC=C1F InChI=1S/C20H15F2N5O2/c21-15-6-1-12(9-16(15)22)7-8-29-18-11-24-10-17-25-26-20(27(17)18)14-4-2-13(3-5-14)19(23)28/h1-6,9-11H,7-8H2,(H2,23,28) INLVQLIAJLYDGP-UHFFFAOYSA-N
MMV1576794 FC1=CC(CCOC2=CN=CC3=NN=C(C4=CC(C(N)=O)=CC=C4)N32)=CC=C1F InChI=1S/C20H15F2N5O2/c21-15-5-4-12(8-16(15)22)6-7-29-18-11-24-10-17-25-26-20(27(17)18)14-3-1-2-13(9-14)19(23)28/h1-5,8-11H,6-7H2,(H2,23,28) SUVZMBHYRLCWQO-UHFFFAOYSA-N
MMV1576795 FC1=CC(CCOC2=CN=CC3=NN=C(C4=CC=C(C(N(C)C)=O)C=C4)N32)=CC=C1F InChI=1S/C22H19F2N5O2/c1-28(2)22(30)16-6-4-15(5-7-16)21-27-26-19-12-25-13-20(29(19)21)31-10-9-14-3-8-17(23)18(24)11-14/h3-8,11-13H,9-10H2,1-2H3 VILLYIKHHVUPAT-UHFFFAOYSA-N
MMV1576796 BrC1=NN=C2C=NC=C(OCCC3=CC(F)=C(F)C=C3)N21 InChI=1S/C13H9BrF2N4O/c14-13-19-18-11-6-17-7-12(20(11)13)21-4-3-8-1-2-9(15)10(16)5-8/h1-2,5-7H,3-4H2 MNOZFILPXCZGRJ-UHFFFAOYSA-N