Amino-thienopyrimidine Series

Mnr: MNR51-60
See - Synthesis on JRC13-4
- Synthesis on JRC17-2




Hazard Assessment

Procedure

reaction on at 1600pm 21/11/12

JRC13-4 (0.1 g, 0.586 mmol) was dissolved in methanol (7 mL) and stirred at rt. To the stirring solution was added 2methylindole(0.115 g, 0.88 mmol). The resultant solution was stirred at rt for XX hours.

The reaction was then concentrated and extract xtracted with EtOAc (10 mL), washed with water (2 x 10 mL), organic dried over MgSO4 to yield a XXX

Frac 36-51 - 0.063 g, not SM or product

NMR

Fraction 21-30 - Starting material


Fraction 36-51 - Major spot


JRC15-4

Mnr: MNR51-60
See - Synthesis on JRC13-4
- Synthesis on JRC17-2




Hazard Assessment

Procedure

reaction on at 1600pm 21/11/12

JRC13-4 (0.1 g, 0.586 mmol) was dissolved in methanol (7 mL) and stirred at rt. To the stirring solution was added 2,5-dimethylpyrrole(0.09 mL, 0.88 mmol) dropwise. The resultant solution was stirred at rt for XX hours.

The reaction was then concentrated and extract xtracted with EtOAc (10 mL), washed with water (2 x 10 mL), organic dried over MgSO4 to yield a XXX

Mnr: MNR51-60
See - Synthesis on JRC13-4
- Synthesis on JRC17-2




Hazard Assessment

Procedure

reaction on at 1600pm 21/11/12

JRC13-4 (0.1 g, 0.586 mmol) was dissolved in methanol (7 mL) and stirred at rt. To the stirring solution was added pyrrole (0.061 mL, 0.88 mmol) dropwise. The resultant solution was stirred at rt for XX hours.

The reaction was then concentrated and extract xtracted with EtOAc (10 mL), washed with water (2 x 10 mL), organic dried over MgSO4 to yield a XXX

Frac 8-11 0.029 g - SM
Frac 26-50 0.062 g - not product, not SM

NMR

Fraction 8-11 - Starting material


Fraction 26-50 - Major spot