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15th March 2013 @ 03:51

Ref R1 R2 R3 Catalyst Base Solvent Yield
MNR104-1 morpholine H H PdCl2(dppf) K2CO3 IPA 83 %
AT-7-2 Ph  H Pd-118  K2CO3  IPA 76 % 
AT-7-1 Ph  PdCl2(dppf)  K2CO3  IPA 76 %
AT-9-1 NH2 H H PdCl2(dppf) K2CO3 IPA  91 %
MNR106-1 morpholine  3-SO2NH2  pinacol ester PdCl2(dppf)  K2CO3  IPA   29 %
AT-10-1 NH2 4-SO2NH2  pinacol ester PdCl2(dppf)  K2CO3  IPA   -- *
AT-10-2 NH2  4-SO2NH2  pinacol ester  PdCl2(dppf)   K2CO3  dioxane  TBC
AT-11-1 NH2 3-SO2NH2  pinacol ester PdCl2(dppf)  K2CO3  IPA   25%
AT-11-2 NH2 3-SO2NH2  pinacol ester  PdCl2(dppf)  K2CO3  dioxane  TBC
MNR110-1 morpholine 4-SO2NH2 pinacol ester  PdCl2(dppf)  K2CO3  IPA   traces **
MNR111-1 morpholine  3-CONMe2 pinacol ester  PdCl2(dppf)  K2CO3 IPA  traces **
AT-12-1  NH2  benzyl pinacol ester   PdCl2(dppf)   K2CO3  IPA  72 % **

* - reaction didn't go to plan due to contamination 

** - NMR's not clear so exact yields not calculated

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