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21st May 2013 @ 04:37
Procedure: MNR 99-3 (300 mg, 1.76 mmol, 1 equiv.) was stirred in ethanolamine (10% in water, 10.6 mL, 17.6 mmol, 10 equiv.) at 100 ˚C for 1 h. AFter 1 h, no SM present on TLC although product couldn't be clearly seen either. Reaction mixture remains orange solution. Reaction was stopped and cooled to room temperature then partitioned between EtOAc and water. The aqueous phases were extracted with EtOAc then combined org. phases washed with brine, dried (MgSO4), filtered and evaporated to yield  Data: Hazard and Risk Assessment: [data]6452[/data] InChi: InChI=1S/C6H3ClN2S/c7-6-5-4(1-2-10-5)8-3-9-6/h1-3H and InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2 to InChI=1S/C8H9N3OS/c12-3-2-9-8-7-6(1-4-13-7)10-5-11-8/h1,4-5,12H,2-3H2,(H,9,10,11)
Attached Files
AEW 57-1.png
HIRAC AEW 57-1.pdf