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21st May 2013 @ 04:37

AEW 57-1 Scheme

Procedure:

MNR 99-3 (300 mg, 1.76 mmol, 1 equiv.) was stirred in ethanolamine (10% in water, 10.6 mL, 17.6 mmol, 10 equiv.) at 100 ˚C for 1 h.

AFter 1 h, no SM present on TLC although product couldn't be clearly seen either. Reaction mixture remains orange solution. Reaction was stopped and cooled to room temperature then partitioned between EtOAc and water. The aqueous phases were extracted with EtOAc then combined org. phases washed with brine, dried (MgSO4), filtered and evaporated to yield 

Data:

Hazard and Risk Assessment:

HIRAC AEW 57-1.pdf

InChi:

InChI=1S/C6H3ClN2S/c7-6-5-4(1-2-10-5)8-3-9-6/h1-3H

and

InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2

to

InChI=1S/C8H9N3OS/c12-3-2-9-8-7-6(1-4-13-7)10-5-11-8/h1,4-5,12H,2-3H2,(H,9,10,11)

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Attached Files
AEW 57-1.png
HIRAC AEW 57-1.pdf