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25th March 2013 @ 04:30
Synthesis of thienopyrimidine (MNR89-2) from methyl-3-aminothiophene-2-carboxylate As for [blog=6514]Synthesis of thienopyrimidine MNR89-1[/blog] [blog=6927]Synthesis of thienopyrimidine MNR89-2[/blog] Hazard Assessment [data]4909[/data] Procedure To methyl-3-aminothiophene-2-carboxylate (13.59 g, 86.46 mmol) and ammonium formate (6.0 g, 95.1 mmol) was added formic acid (3.59 mL, 95.1 mmol) and formamide (18.89 mL, 475 mmol) and the mixture was heated to 140 °C.  After 15 hours the reaction was cooled to room temperature and a solid formed.  This was washed with water and filtered to give an off white solid. The crude was recrystalised with EtOH (400 ml) to give fine white crystals.   NMR [data]6121[/data][data]6123[/data][data]6125[/data]  Conclusion Strings Starting Material InChI=1S/C6H7NO2S/c1-9-6(8)5-4(7)2-3-10-5/h2-3H,7H2,1H3 InChI=1S/CH3NO/c2-1-3/h1H,(H2,2,3) Product InChI=1S/C6H4N2OS/c9-6-5-4(1-2-10-5)7-3-8-6/h1-3H,(H,7,8,9)
Attached Files
MNR89-3_table.PNG
mnr89-3_filter_1H.pdf
mnr89-3_filter_13C.pdf
mnr89-3_filter.zip