All Notebooks | Help | Support | About
18th March 2013 @ 04:41

Repeat of AT-10-1, under microwave conditions. 

A solution of AT-6 (0.020 g, 0.87 mmol, 1.0 equiv.), 4-sulfamoylphenyl boronic acid (0.030 g, 0.10 mmol, 1.2 equiv.) and PdCl2dppf (0.013 g, 0.018 mmol, 0.2 equiv.) in isopropanol (2 mL) and K2CO3 (1 M, 0.17 mL, 0.17 mmol, 2.0 equiv.) was heated to 80 C in a microwave reactor (200 W) for 30 minutes. 

The reaction mixture was cooled, diluted with methanol (10 mL) and filtered through Celite. The reaction mixture was concentrated under reduced pressure. The residue was purified by flash column chromatography (95:45:0.5 dichloromethane:methanol:ammonia) to give the product as a brown solid (0.007 g, 26%). Hm. Not sure what happened here. 

 

NMR

AT-10-4.pdf

 

HIRAC

AT-10-4.pdf
Linked Posts
This post is linked by:
Attached Files
AT-10-4.pdf
AT-10-1.jpg
AT-10-4.pdf