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12th June 2014 @ 10:35
  [blog=6938]Amination of bromochlorothienopyrimidine (AT-6-4)[/blog] was repeated on 100 mg of substrate in 2ml of IPA and 4ml of ammonia at 120°C in a sealed tube for 3 hours. The solvents were removed in vacuo and the resulting orange solid was sufficiently pure to use as-is (B1, 102 mg, quantitative yield with 1eq ammonium chloride)
Attached Files
PT-21.png
PT-21-B1.pdf
CJCOSDD_ptm21b1meod_120614_1H_av600.tar