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1st November 2017 @ 14:23

VTM007

23/10/2017

VTM007.jpg

 

VTM004 (0.03 g, 0.07 mmol) was dissolved in toluene (2 mL). Pyrrolidine (0.006 g, 0.084 mmol), NaO t Bu (9 mg, 98 µmol), JohnPhos (0.9 mg, 3 µmol) and Pd 2 (dpa) 3 (0.3 mg, 0.35 µmol) were added in this order to the solution and the mixture was heated at 80 °C for 16 hours. TLC analysis showed the presence of large quantities of the starting material.

VTM007 TLC.jpg

The temperature was increased to 100 °C and the reaction left to stir for two weeks.

Attached Files
VTM007.jpg
VTM007 TLC.jpg