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30th January 2014 @ 14:37

Methyl 6-chloro-2-pyrazinecarboxylate (1.03 g, 10.3 mmol) from sample 3/4 of EO 6-2 was dissolved in EtOH (14.5 mL). 2M NaOH (14.5 mL) was added, and the reaction stirred at ambient temperature for 2 h. The reaction mixture was acidified to pH3 with 2M HCl (aq). The mixture was then diluted with water (86.80 mL) and extracted with EtOAc (4 x 57.87 mL). The organic extracts were combined, washed with brine (57.87 ml) dried over Na2SO4, filtered and concentrated under vacuum to provide the title compound as a white solid (0.63 g, xx %).  NMR was derived.

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EO 7-3 1H NMR.pdf