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25th September 2013 @ 04:36

 

Started 21:05

2,6-Dichloropyrazine (1 g, 6.7 mmol) was vigorously stirred in ethanol (10 mL) and hydrazine hydrate (0.33 mL, 340 mg, 6.7 mmol) was added. The resulting mixture was heated at 80 ˚C for 12 h.

After completion (monitored by TLC, 30% EtOAc in Hexane, Rf = 0.2) solvent was removed under vacuo to yield a crude orange solid (940 mg, 6.5 mmol, 97% crude yield).

Data:

TLC 12 h, 30% EtoAc in Hex (doesn't stain very well in vanillin)

AEW 85-1 30%EtOAcinHex.jpg

1H NMR (300 MHz, CDCl3) δ: 8.14 (1H, s), 7.90 (1H, s), 6.37 (1H, s), 3.80 (2H, bs).

AEW 85-1 PROTON.pdf
AEW 85-1.zip

Hazard and Risk Assessment:

HIRAC AEW 85-1.pdf

InChi Strings:

InChI=1S/C4H2Cl2N2/c5-3-1-7-2-4(6)8-3/h1-2H

to

InChI=1S/C4H5ClN4/c5-3-1-7-2-4(8-3)9-6/h1-2H,6H2,(H,8,9)

Linked Entries
Attached Files
AEW 85-1.png
HIRAC AEW 85-1.pdf
AEW 85-1 30%EtOAcinHex.jpg
AEW 85-1 PROTON.pdf
AEW 85-1.zip