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6th August 2014 @ 05:56

TM 42, 43, and 44 are hydrazones that will be cyclised to give three triazolopyrazines with a pyridine ring as the triazolo- substituent, together with the known-potent 3-chloroanilide pyrazinyl substitutent.

scheme

 

TM 8-3 (Resynthesis of N-(3-chlorophenyl)-6-hydrazinylpyrazine-2-carboxamide (TM 8-3): 200 mg, 0.758 mmol) was combined with 2-formylpyrazine (81 mg, 1 eq) in MeCN (3 mL), and catalytic AcOH (3 drops), and stirred for ?? h.

InChIs:

InChI=1S/C11H10ClN5O/c12-7-2-1-3-8(4-7)15-11(18)9-5-14-6-10(16-9)17-13/h1-6H,13H2,(H,15,18)(H,16,17)

InChI=1S/C6H5NO/c8-5-6-3-1-2-4-7-6/h1-5H

to

InChI=1S/C17H13ClN6O/c18-12-4-3-6-13(8-12)22-17(25)15-10-19-11-16(23-15)24-21-9-14-5-1-2-7-20-14/h1-11H,(H,22,25)(H,23,24)/b21-9+

HIRAC:

42-1 hirac.pdf
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Attached Files
scheme.png
42-1 hirac.pdf