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12th February 2013 @ 05:12
Mnr: MNR91-100

Attempted Solvent Free, 1-Pot Synthesis of Ether MNR98-2 

Starting material AEW2-2

 Hazard Assessment

HIRAC MNR98.pdf

Procedure

Methyl bromoacetate (1 mL, 10.2 mmol) was added to a flask with tpye 3A molecular sieve powder and AEW2-2 (0.10 g, 0.46 mmol) was added.  Sodium borohydride (19 mg, 0.51 mmol) was added and the reaction was allowed to stir at room temperature overnight.  TLC in the morning showed no reaction, so it was left.  After 24 hours TLC still showed no reaction and was not taken any further. 

Strings

Starting material

InChI=1S/C13H12FNO/c1-9-7-11(8-16)10(2)15(9)13-5-3-12(14)4-6-13/h3-8H,1-2H3

Product

InChI=1S/C16H18FNO3/c1-11-8-13(9-21-10-16(19)20-3)12(2)18(11)15-6-4-14(17)5-7-15/h4-8H,9-10H2,1-3H3

 

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Attached Files
MNR98-2_table.PNG
MNR98-2_scheme.png
HIRAC MNR98.pdf