All Notebooks | Help | Support | About
26th November 2012 @ 04:30
Mnr: MNR61-70
EDC Coupling of PMY59-3 with Ammonium Hydroxide to give MNR62-1

See - Synthesis of AEW16-1
- Synthesis of MNR52-1
Carbodiimide couplings


Hazard Assessment


reaction on at 300pm 26/11/12

EDCI (0.027, 0.14 mmol) and HOBt (0.002 g, 0.01 mmol) were added to a solution of PMY59-3 (0.035 g, 0.12 mmol) in DCM (2 mL) and the mixture was stirred for 20 minutes, during which time it became a clear solution. Ammonium hydroxide(28%, 0.1 mL) was added and the reaction and iy turned a cloudy white colour and the mixture was stirred at room temperature.

After stirring overnight the TLC still showed signs of starting material but it was decided to work the reaction up. It was quenched with sodium bicarbonate (10 mL) and extracted with DCM (3 x 10 mL), dried over MgSO4, filtered and concentrated to give a brown oil (0.105 g)
Linked Posts
This post is linked by:
Attached Files