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26th November 2012 @ 04:30
Mnr: MNR61-70
EDC Coupling of PMY59-3 with Ammonium Hydroxide to give MNR62-1

See - Synthesis of AEW16-1
- Synthesis of MNR52-1
Carbodiimide couplings

MNR62_scheme.png
MNR62-1_table.PNG

Hazard Assessment
HIRAC MNR54.pdf


Procedure

reaction on at 300pm 26/11/12

EDCI (0.027, 0.14 mmol) and HOBt (0.002 g, 0.01 mmol) were added to a solution of PMY59-3 (0.035 g, 0.12 mmol) in DCM (2 mL) and the mixture was stirred for 20 minutes, during which time it became a clear solution. Ammonium hydroxide(28%, 0.1 mL) was added and the reaction and iy turned a cloudy white colour and the mixture was stirred at room temperature.

After stirring overnight the TLC still showed signs of starting material but it was decided to work the reaction up. It was quenched with sodium bicarbonate (10 mL) and extracted with DCM (3 x 10 mL), dried over MgSO4, filtered and concentrated to give a brown oil (0.105 g)
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Attached Files
MNR62-1_table.PNG
MNR62_scheme.png