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16th October 2012 @ 00:07
AEW%2014-1.png

AEW 10-1 (2 g, 8.54 mmol, 1 equiv.) was dissolved in DCM (86 mL) under Argon. EDC (1.98 g, 10.3 mmo, 1.2 equiv.) and HOBt (120 mg, 0.86 mmol. 0.1 equiv.) were added and the yellow solution stirred at room temperature for 20 minutes under Argon. Hydrazine hydrate (0.98 mL, 12.9 mmol, 1.5 equiv) was injected in a single portion.

TLC :

1H NMR:

Hazard and Risk Assessment:

See AEW 14-1 but on 10 x greater scale....weigh out HOBt with caution

HIRAC AEW 14-1.pdf
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