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Second Step: Synthesis of 2,6-dichloro-3,5-dimethylpyrazine (HASJK-3-1)
Second Step: Synthesis of 2,6-dichloro-3,5-dimethylpyrazine Column Chromatography (HASJK-3-2)
Step Four: Synthesis of (E)-2-chloro-6-(2-(4-(difluoromethoxy)benzylidene)hydrazineyl)-3,5-dimethylpyrazine
Third Step: Synthesis of 2-chloro-6-hydrazineyl-3,5-dimethylpyrazine (HASJK-3-3)
- December 2016 (5)
- Templates (5)
Columned on 11/28/16
The product was columned by the Biotage. The fractions 5-7 (high spots) were combined. The product was a white crystal. Fractions 19-30 were also combined (low spot). NMR was run on the high spot. Initial look suggests that the chlorinated dimethyl product was synthesized with traces of starting material. Ran NMR/GCMS on both high and low spots, shown below.
Silica gel plates. 50/50 EtoAc/Hexane. Active under UV light.