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8th May 2014 @ 03:00
Osm: OSM-S-211_to_OSM-S-220

Original Sources

Original synthesis found in MMV briefing document found in this post:A New Triazolopyrazine Series for OSM - Series 4

Other attempts:

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-8)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-7)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-6)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-5)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-4)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-3)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-2)

Synthesis of 4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (JU 3-1)

 

Synthesis of 4-(5-chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-9)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-8)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-7)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-6)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-5)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-4)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-3)

4-(5-Chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 97-2)


GitHub Link

 

Biological Data

Single Shot Potencies for Compounds Submitted to GSK

Synonyms

AEW 97

JU 3

ClC1=CN=CC2=NN=C(C3=CC=C(C#N)C=C3)N21

InChI=1S/C12H6ClN5/c13-10-6-15-7-11-16-17-12(18(10)11)9-3-1-8(5-14)2-4-9/h1-4,6-7H

IXZMOLDGRAEJRY-UHFFFAOYSA-N

4-(5-chloro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile

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Attached Files
OSM-S-219.cdxml
OSM-S-219.png