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8th May 2014 @ 01:38
Osm: OSM-S-211_to_OSM-S-220

(number in above picture is wrong - should be MMV669844)

Original Sources

Compound originally sourced from MMV as an enantiomerically enriched compound (MMV669844). OSM inherited data at start of Series 4 project.

Related is the synthesis of the racemate (OSM-S-208, GitHub Tag: #166)

Synthesis of 4-(5-(2-(3,4-difluorophenyl)-2-methoxyethoxy)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile (AEW 145-1)

 

Biological Data

??? - data inherited.

Metabolism ID Study for Three Triazolopyrazines

Assay Methods for Inherited Series 4 Compounds

Evaluation against Pb. Liver Schizonts

hERG Data

Related links:

Similarity of Series 4 Compounds to KAI407

Data for racemate (OSM-S-208) 

Synonyms

MMV669844

FC1=C(F)C=CC([C@@H](OC)COC2=CN=CC3=NN=C(C4=CC=C(C#N)C=C4)N32)=C1

InChI=1S/C21H15F2N5O2/c1-29-18(15-6-7-16(22)17(23)8-15)12-30-20-11-25-10-19-26-27-21(28(19)20)14-4-2-13(9-24)3-5-14/h2-8,10-11,18H,12H2,1H3

PERKBMZWWUEZNJ-UHFFFAOYSA-N

(R)-4-(5-(2-(3,4-difluorophenyl)-2-methoxyethoxy)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)benzonitrile

Attached Files
OSM-S-218.cdxml
OSM-S-218.png