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27th March 2013 @ 02:02
Osm: OSM-S-101_to_OSM-S-110


Original Sources

 Suzuki coupling using the same conditions that are used to generate boronate esters (JRC 50-2)

Synthesis of 3-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide (AB5-1) and 4-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide (AB6-1)

Repeat of the Suzuki coupling used in JRC50-2 - (MNR86-1)

Repeat of the Suzuki coupling used in JRC50-2 (AB8-1)

Upscaled repeat of the Suzuki coupling used in JRC50-2 (AB8-2)

Synthesis of 3-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide JRC 42-1 - early failed attempt

Github Issue 59

Biological Data

3D7 - Avery - Biological Activities of OSM-S-106 through 116

Late Stage Gametocyte Assay

Compounds sent for parasiste ion regulation assays at ANU

Compound List from Early Series to be sent to Kiaran Kirk

Liver stage malaria activities of OSM-S-106 and OSM-S-111 in Plasmodium berghei.

Metabolic and Kinetic Solubility Data for OSM-S-106 and OSM-S-111

Single Shot Potencies for Compounds Submitted to GSK

Ion Regulation Assay for OSM Series 1 and 3






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