Experimental Procedures

 

Osm: OSM-S-61_to_OSM-S-70

Original Sources

Upscaled synthesis of 4-chlorothieno[3,2-d]pyrimidine (JRC 13-3)

Synthesis of 4-chlorothieno[3,2-d]pyrimidine (AB2-1)

Synthesis of 4-chlorothieno[3,2-d]pyrimidine (JRC 13-2)

Synthesis of 4-chlorothieno[3,2-d]pyrimidine (JRC 13-1)

Upscaled synthesis of 4-chlorothieno[3,2-d]pyrimidine (JRC 13-4)

Upscaled synthesis of 4-chlorothieno[3,2-d]pyrimidine (JRC 13-5)

Upscaled synthesis of 4-chlorothieno[3,2-d]pyrimidine (JRC 13-6)

Chlorination of MNR89 To Give MNR99-1

Chlorination of MNR89 To Give MNR99-2

Synthesis of 4-chlorothienopyrimidine (AT-1-1)

Synthesis of chlorothienopyrimidine (AT-1-2)   << 96% yield

Synthesis of chlorothienopyrimidine (AT-1-3)

Biological Data

3D7 - Avery - Preliminary Results for Phase 1 or Round 3 of Screening

Synonyms

JRC 13
MNR 99
AT 1
AB 2

Clc1ncnc2ccsc12

InChI=1S/C6H3ClN2S/c7-6-5-4(1-2-10-5)8-3-9-6/h1-3H

TWTODSLDHCDLDR-UHFFFAOYSA-N

4-chlorothieno[3,2-d]pyrimidine