Experimental Procedures

Original Sources

Synthesis of p-methyl arylpyrrole based near neighbour (ZYH 5-1)

Synthesis of (2Z,5Z)-5-((2,5-dimethyl-1-(p-tolyl)-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one (AEW 76-1, OSM-S-37)

Synthesis of (2Z,5Z)-5-((2,5-dimethyl-1-(p-tolyl)-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

Metabolism - Metabolism and Solubility Results

GSK DHODH Assay

Synonyms

ZHY 5, AEW 76

CC1=CC=C(N2C(C)=C(/C=C(C(N/3)=O)\SC3=N/C4=CC=CC=C4)C=C2C)C=C1

InChI=1S/C23H21N3OS/c1-15-9-11-20(12-10-15)26-16(2)13-18(17(26)3)14-21-22(27)25-23(28-21)24-19-7-5-4-6-8-19/h4-14H,1-3H3,(H,24,25,27)/b21-14-

XCTPMKNSBDOHRB-STZFKDTASA-N

(2Z,5Z)-5-((2,5-dimethyl-1-(p-tolyl)-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one