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26th March 2013 @ 06:26
Osm: OSM-S-31_to_OSM-S-40

OSM-S-35

Original Sources

Synthesis of Near Neighbour Analog MNR93-1

Synthesis of phenyliminothiazolidinone-substituted arylpyrrole (ZYH 3-1)

Synthesis of 4-H near neighbour ZYH 3-1 (PMY 47-1)

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

hERG - hERG Assay for OSM-S-35 (ZYH 3-1) and OSM-S-5 (PMY 10)

In vivoIn vivo Plasmodium Berghei mouse trial of initial leads

Ion Regulation Assay for OSM Series 1 and 3

GSK DHODH Assay

Synonyms

ZYH 3, PMY 47, MNR 93

CC(N1C2=CC=CC=C2)=CC(/C=C(C(N/3)=O)\SC3=N/C4=CC=CC=C4)=C1C

InChI=1S/C22H19N3OS/c1-15-13-17(16(2)25(15)19-11-7-4-8-12-19)14-20-21(26)24-22(27-20)23-18-9-5-3-6-10-18/h3-14H,1-2H3,(H,23,24,26)/b20-14-

QTDBAHFMTAMGMZ-ZHZULCJRSA-N

(2Z,5Z)-5-((2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one

Linked Posts
Attached Files
OSM-S-35.cdx
OSM-S-35.png