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26th March 2013 @ 06:14
Osm: OSM-S-21_to_OSM-S-30

OSM-S-21

Original Sources

Coupling of pyrrole carboxylic acid PMY 8-4 and glycinamide derivative PMY30-3 (PMY 34-1)

Synthesis of N-(2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-2-oxoethyl)-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxamide (OSM-S-21), AEW 65-1

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

GSK DHODH Assay

Synonyms

PMY 34, AEW 65

FC1=CC=C(N2C(C)=CC(C(NCC(NC3=C(C)N(C)N(C4=CC=CC=C4)C3=O)=O)=O)=C2C)C=C1

InChI=1S/C26H26FN5O3/c1-16-14-22(17(2)31(16)20-12-10-19(27)11-13-20)25(34)28-15-23(33)29-24-18(3)30(4)32(26(24)35)21-8-6-5-7-9-21/h5-14H,15H2,1-4H3,(H,28,34)(H,29,33)

RRYQCWKAZAVYJI-UHFFFAOYSA-N

N-(2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-2-oxoethyl)-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxamide

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Attached Files
OSM-S-21.cdx
OSM-S-21.png