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26th March 2013 @ 06:08
Osm: OSM-S-11_to_OSM-S-20

OSM-S-19

Original Sources

Failed: Coupling of pyrrole carboxylic acid PMY 8-3 and glycinamide (PMY 31-1)

Failed: Coupling of pyrrole carboxylic acid PMY 8-3 and glycinamide (PMY 31-2)

Failed: Coupling of pyrrole carboxylic acid PMY 8-3 and glycinamide (PMY 31-3)

Failed: Coupling of pyrrole carboxylic acid PMY 8-3 and glycinamide (PMY 31-4)

Coupling of pyrrole acid chloride PMY 32-2 and glycinamide (PMY 31-5)

Failed: Resynthesis of N-(2-amino-2-oxoethyl)-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxamide, OSM-S-19 (AEW 59-1)

Resynthesis of N-(2-amino-2-oxoethyl)-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxamide, OSM-S-19 (AEW 59-2)

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - Ralph - Second Round Biological evaluation by James Pham and Stuart Ralph

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

GSK DHODH Assay

Synonyms

PMY 31, AEW 59

CC(N1C2=CC=C(F)C=C2)=CC(C(NCC(N)=O)=O)=C1C

InChI=1S/C15H16FN3O2/c1-9-7-13(15(21)18-8-14(17)20)10(2)19(9)12-5-3-11(16)4-6-12/h3-7H,8H2,1-2H3,(H2,17,20)(H,18,21)

NNGDJLZNBQLHHL-UHFFFAOYSA-N

N-(2-amino-2-oxoethyl)-1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxamide

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Attached Files
OSM-S-19.cdx
OSM-S-19.png