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26th March 2013 @ 05:28
Osm: OSM-S-1_to_OSM-S-10

OSM-S-10

Original Sources

Hydrolysis of acyl-iminothiazolidinone PMY 14-1 (PMY 16-1)

Attempt: Synthesis of phenyliminothiazolidinone-substituted arylpyrrole (PMY 14-1)

Synthesis of phenyliminothiazolidinone-substituted arylpyrrole (PMY 14-2)

Synthesis of phenyliminothiazolidinone-substituted arylpyrrole (PMY 14-3)

Synthesis of 4-Fluoro substituted near neighbour (PMY 14-4)

Resynthesis of (2Z,5Z)-5-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one (AEW 80-1, OSM-S-10)

Reduction of 4-fluoro near-neighbour (N-H) Michael-acceptor (PMY 39-1)

Biological Data

3D7, K1 and HEK293 - Avery - Second Round of Evaluation by the Avery Lab

3D7 - GSK - Second Round of Evaluation by GSK Tres Cantos

Metabolism - Metabolism and Solubility Results

Plasma - Human and Mouse Plasma Stability of OSM-S-5/PMY 10-6

Pharmacokinetics - Pharmacokinetics of OSM-S-5/TCMDC-123812/PMY 10-6

Synonyms

PMY 14, AEW 80

CC(N1C2=CC=C(F)C=C2)=C(/C=C(C(N/3)=O)\SC3=N/C4=CC=CC=C4)C=C1C

InChI=1S/C22H18FN3OS/c1-14-12-16(15(2)26(14)19-10-8-17(23)9-11-19)13-20-21(27)25-22(28-20)24-18-6-4-3-5-7-18/h3-13H,1-2H3,(H,24,25,27)/b20-13-

IMCPBTMVWRMBHR-MOSHPQCFSA-N

(2Z,5Z)-5-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methylene)-2-(phenylimino)thiazolidin-4-one

Attached Files
OSM-S-10.cdx
OSM-S-10.png