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26th March 2013 @ 05:22
Osm: OSM-S-1_to_OSM-S-10

OSM-S-9

Original Sources

Acetylation of 4-fluoro near neighbour PMY 14-4 (PMY 35-1)

Accidental synthesis: Synthesis of phenyliminothiazolidinone-substituted arylpyrrole (PMY 14-1)

Accidental synthesis: Synthesis of phenyliminothiazolidinone-substituted arylpyrrole (PMY 14-2)

Biological Data

3D7, K1 and HEK293 - Avery - Second Analysis of First Set of Compounds (Avery)

3D7 - GSK - Re-evaluation of TCMDC-123794, TCMDC-123812 and others by GSK Tres Cantos

Metabolism - Metabolism and Solubility Results

Plasma - Human and Mouse Plasma Stability of OSM-S-5/PMY 10-6

Pharmacokinetics - Pharmacokinetics of OSM-S-5/TCMDC-123812/PMY 10-6

Synonyms

PMY 14, PMY 35

FC1=CC=C(C=C1)N2C(C)=CC(/C=C(SC(N(C3=CC=CC=C3)C(C)=O)=N4)/C4=O)=C2C

InChI=1S/C24H20FN3O2S/c1-15-13-18(16(2)27(15)21-11-9-19(25)10-12-21)14-22-23(30)26-24(31-22)28(17(3)29)20-7-5-4-6-8-20/h4-14H,1-3H3/b22-14-

WFLINPFRLHPFGO-HMAPJEAMSA-N

(Z)-N-(5-((1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methylene)-4-oxo-4,5-dihydrothiazol-2-yl)-N-phenylacetamide

Attached Files
OSM-S-9.cdx
OSM-S-9.png