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26th March 2013 @ 05:15
Osm: OSM-S-1_to_OSM-S-10

OSM-S-6


Original Sources

Synthesis of TCMDC-123794 via acid chloride (PMY 11-1)

Synthesis of TCMDC-123794 via acid chloride (PMY 11-2)

Synthesis of TCMDC-123794 using DIC/DMAP (PMY 11-3)

Attempt: Synthesis of TCMDC-123794 via acid chloride (PMY 11-4)

Synthesis of TCMDC-123794 via acid chloride, improved method (PMY 11-5)

Synthesis of TCMDC-123794 via acid chloride, improved method (PMY 11-6)

Biological Data

3D7, K1 and HEK293 - Avery - Second Analysis of First Set of Compounds (Avery)

3D7 - GSK - Re-evaluation of TCMDC-123794, TCMDC-123812 and others by GSK Tres Cantos

Metabolism - Metabolism and Solubility Results

In vivo - In vivo Plasmodium Berghei mouse trial of initial leads

Plasma - Human and Mouse Plasma Stability of OSM-S-5/PMY 10-6

Pharmacokinetics - Pharmacokinetics of OSM-S-5/TCMDC-123812/PMY 10-6

HIP-HOP - HIP-HOP mechanism of action studies from Corey Nislow's Lab

 

Synonyms

TCMDC-123794

PMY 11

CC(N1C2=CC=C(F)C=C2)=CC(C(OCC(NC(C3=O)=C(N(N3C4=CC=CC=C4)C)C)=O)=O)=C1C

InChI=1S/C26H25FN4O4/c1-16-14-22(17(2)30(16)20-12-10-19(27)11-13-20)26(34)35-15-23(32)28-24-18(3)29(4)31(25(24)33)21-8-6-5-7-9-21/h5-14H,15H2,1-4H3,(H,28,32)

OFHDGHFNTKVFPI-UHFFFAOYSA-N

Attached Files
OSM-S-6.cdx
OSM-S-6.png