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26th March 2013 @ 04:55
Osm: OSM-S-1_to_OSM-S-10

OSM-S-4

Context

OSM Series 1

Original Sources

Oxidation of pyrrole-3-carbaldehyde PMY 2-2, to corresponding acid (PMY 3-1)

Oxidation of pyrrole-3-carbaldehyde PMY 2-2, to corresponding acid (PMY 3-2)

Sodium chlorite oxidation of Pyrrole-3-carbaldehyde PMY 2-2, to corresponding acid (PMY 3-3)

Oxone oxidation of Pyrrole-3-carbaldehyde PMY 2-3, to corresponding acid (PMY 3-4)

Pinnick Oxidation of Pyrrole-3-carbaldehyde PMY 2-3, to corresponding acid (PMY 3-5)

Comparison of Chlorite and Permanganate in the Oxidation of Pyrrole-3-carbaldehyde PMY 2-3, to corresponding acid (PMY 3-6)

Oxidation of Pyrrole-3-carbaldehyde PMY 2-3, to corresponding acid using hydrogen peroxide (PMY 3-7)

Pinnick Oxidation of Pyrrole-3-carbaldehyde, to corresponding acid (PMY 3-8)

Jones Oxidation of Pyrrole-3-carbaldehyde, to Corresponding Acid (PMY 3-9)

TEMPO/bleach oxidation of Pyrrole-3-carbaldehyde PMY 2-4, to corresponding acid (PMY 3-10)

Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (PMY 8-1)

Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (PMY 8-2)

Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (PMY 8-3)

Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (PMY 8-4)

Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (JRC 2-1)

Hydrolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (AEW 10-1)

Hydrolysis of AEW7-2 to give MNR57-1

Synthesis of 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylic acid (AEW 10-2)

Hyrdolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (MD 2-1)

Hyrdolysis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (MD 2-2)

Biological Data

3D7, K1 and HEK293 - Avery - Second Analysis of First Set of Compounds (Avery)

3D7 - GSK - Re-evaluation of TCMDC-123794, TCMDC-123812 and others by GSK Tres Cantos

Ion Regulation Assay for OSM Series 1 and 3

First Set of Biological Data

GSK DHODH Assay

Synonyms

PMY 3, PMY 8, JRC 2, AEW 10, MNR 57

CC(N1C2=CC=C(F)C=C2)=C(C(O)=O)C=C1C

InChI=1S/C13H12FNO2/c1-8-7-12(13(16)17)9(2)15(8)11-5-3-10(14)4-6-11/h3-7H,1-2H3,(H,16,17)

UHSNGSYVRLIXCX-UHFFFAOYSA-N

1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylic acid

Literature

At time of first synthesis, and at time of writing, compound is novel.

Linked Posts
Attached Files
OSM-S-4.cdx
OSM-S-4.png