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26th March 2013 @ 04:15
Osm: OSM-S-1_to_OSM-S-10

OSM-S-3

Context

OSM Series 1

Original Sources

Friedel-Crafts Acylation of Pyrrole core PMY 1-6 to Obtain Ethyl Pyrrole-3-carboxylate (PMY 4-1)

Friedel-Crafts Acylation of Pyrrole core PMY 1-6 to Obtain Ethyl Pyrrole-3-carboxylate (PMY 4-2)

Synthesis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (PMY 6-1)

Synthesis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (PMY 6-2)

Upscaled Synthesis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (JRC 1-1)

Synthesis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (AEW 7-1)

Synthesis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (AEW 7-2)

Synthesis of ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (AEW 7-3)

Synthesis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (MD 1-1)

Synthesis of Ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (MD 1-2)

Biological Data

3D7, K1 and HEK293 - Avery - Second Analysis of First Set of Compounds (Avery)

3D7 - GSK - Re-evaluation of TCMDC-123794, TCMDC-123812 and others by GSK Tres Cantos

Synonyms

PMY 6, JRC 1, AEW 7, MD 1


O=C(C1=C(C)N(C2=CC=C(F)C=C2)C(C)=C1)OCC

InChI=1S/C15H16FNO2/c1-4-19-15(18)14-9-10(2)17(11(14)3)13-7-5-12(16)6-8-13/h5-9H,4H2,1-3H3

BFRWWAGLFICHEG-UHFFFAOYSA-N

ethyl 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate

Literature

At time of first synthesis and writing, compound is novel.

Procedures used:

http://dx.doi.org/10.1021/jo00391a003 and http://dx.doi.org/10.1016/S0040-4020(01)81514-3

Attached Files
OSM-S-3.cdx
OSM-S-3.png