Experimental Procedures

 

Osm: OSM-S-271_to_OSM-S-280

 

Context

OSM Series 4

Original Sources

Inherited 

(830 nM)

A New Triazolopyrazine Series for OSM - Series 4

Biological Data

 

Synonyms

MMV670250

FC1=C(F)C=CC(CCOC2=CN=CC3=CN=C(C4=CC=C(Cl)C=C4)N32)=C1

InChI=1S/C20H14ClF2N3O/c21-15-4-2-14(3-5-15)20-25-11-16-10-24-12-19(26(16)20)27-8-7-13-1-6-17(22)18(23)9-13/h1-6,9-12H,7-8H2

JHORUMGXLQTHAD-UHFFFAOYSA-N

3-(4-chlorophenyl)-5-(3,4-difluorophenethoxy)imidazo[1,5-a]pyrazine

 

Osm: OSM-S-271_to_OSM-S-280

Context

OSM Series 4

Original Sources

Inherited (110 nM)

A New Triazolopyrazine Series for OSM - Series 4

Biological Data

Results of Series 4 Aldehyde Oxidase Assay

Comparisons with Novartis compound:

Similarity of Series 4 Compounds to KAI407

Synonyms

MMV669846

FC1=C(F)C=CC(CCOC2=CN=CC3=NC=C(C4=CC=C(Cl)C=C4)N32)=C1

InChI=1S/C20H14ClF2N3O/c21-15-4-2-14(3-5-15)18-10-25-19-11-24-12-20(26(18)19)27-8-7-13-1-6-16(22)17(23)9-13/h1-6,9-12H,7-8H2

MQHQNFQVEXYAMO-UHFFFAOYSA-N

3-(4-chlorophenyl)-5-(3,4-difluorophenethoxy)imidazo[1,2-a]pyrazine

Osm: OSM-S-271_to_OSM-S-280

 

Context

Series 4

Original Sources

Inherited

A New Triazolopyrazine Series for OSM - Series 4

Biological Data

Much inherited biological data:

Initial Pharmacokinetic and Efficacy Studies on Series 4

Synonyms

MMV639565

FC1=C(F)C=CC(CCOC2=CN=CC3=NN=C(C4=CC=C(Cl)C=C4)N32)=C1

InChI=1S/C19H13ClF2N4O/c20-14-4-2-13(3-5-14)19-25-24-17-10-23-11-18(26(17)19)27-8-7-12-1-6-15(21)16(22)9-12/h1-6,9-11H,7-8H2

PMHUSEXABGDNGS-UHFFFAOYSA-N

3-(4-chlorophenyl)-5-(3,4-difluorophenethoxy)-[1,2,4]triazolo[4,3-a]pyrazine

Osm: OSM-S-271_to_OSM-S-280

Original Sources

Synthesis of N-(3-chlorophenyl)-3-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide (TM 55-1)

Biological Data

N/A

Synonyms

TM 55

O=C(NC1=CC(Cl)=CC=C1)C2=CN=CC(N23)=NN=C3C4=CC=C(OC(F)(F)F)C=C4

InChI=1S/C19H11ClF3N5O2/c20-12-2-1-3-13(8-12)25-18(29)15-9-24-10-16-26-27-17(28(15)16)11-4-6-14(7-5-11)30-19(21,22)23/h1-10H,(H,25,29)

KPPYAXXEDYTONY-UHFFFAOYSA-N

N-(3-chlorophenyl)-3-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide

Osm: OSM-S-261_to_OSM-S-270

Original Sources

Synthesis of N-(3-chlorophenyl)-3-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide (TM 54-1)

Biological Data

N/A

Synonyms

TM 54

O=C(NC1=CC(Cl)=CC=C1)C2=CN=CC(N23)=NN=C3C4=CC=C(OC)C=C4

InChI=1S/C19H14ClN5O2/c1-27-15-7-5-12(6-8-15)18-24-23-17-11-21-10-16(25(17)18)19(26)22-14-4-2-3-13(20)9-14/h2-11H,1H3,(H,22,26)

PVPGYERJOUVPIJ-UHFFFAOYSA-N

N-(3-chlorophenyl)-3-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide