- March 2015 (3)
- September 2014 (2)
- August 2014 (63)
- July 2014 (10)
- May 2014 (44)
- April 2014 (12)
- February 2014 (23)
- January 2014 (3)
- October 2013 (1)
- April 2013 (7)
- March 2013 (129)
- November 2012 (4)
- Compound List (1)
- Experimental (294)
- OSM Series Breakdown (6)
- OSM-E-10 to OSM-E-19 (5)
- OSM-E-1 to OSM-E-9 (9)
- OSM-L-1 to 10 (2)
- OSM-S-101 to OSM-S-110 (10)
- OSM-S-111 to OSM-S-120 (10)
- OSM-S-11 to OSM-S-20 (10)
- OSM-S-121 to OSM-S-130 (10)
- OSM-S-131 to OSM-S-140 (10)
- OSM-S-141 To OSM-S-150 (10)
- OSM-S-151 To OSM-S-160 (10)
- OSM-S-161 To OSM-S-170 (10)
- OSM-S-171 To OSM-S-180 (10)
- OSM-S-181 to OSM-S-190 (8)
- OSM-S-191 to OSM-S-200 (9)
- OSM-S-1 to OSM-S-10 (10)
- OSM-S-201 to OSM-S-210 (9)
- OSM-S-211 to OSM-S-220 (11)
- OSM-S-21 to OSM-S-30 (10)
- OSM-S-221 to OSM-S-230 (11)
- OSM-S-231 to OSM-S-240 (10)
- OSM-S-241 to 250 (10)
- OSM-S-251 to 260 (10)
- OSM-S-261 to OSM-S-270 (10)
- OSM-S-271 to OSM-S-280 (4)
- OSM-S-31 to OSM-S-40 (10)
- OSM-S-41 to OSM-S-50 (10)
- OSM-S-51 to OSM-S-60 (10)
- OSM-S-61 to OSM-S-70 (10)
- OSM-S-71 to OSM-S-80 (10)
- OSM-S-81 to OSM-S-90 (10)
- OSM-S-91 to OSM-S-100 (10)
- Series 1 (1)
- OSM-S-1 to (1)
Context
Original Sources
Inherited
(830 nM)
A New Triazolopyrazine Series for OSM - Series 4
Biological Data
Synonyms
MMV670250
FC1=C(F)C=CC(CCOC2=CN=CC3=CN=C(C4=CC=C(Cl)C=C4)N32)=C1
InChI=1S/C20H14ClF2N3O/c21-15-4-2-14(3-5-15)20-25-11-16-10-24-12-19(26(16)20)27-8-7-13-1-6-17(22)18(23)9-13/h1-6,9-12H,7-8H2
JHORUMGXLQTHAD-UHFFFAOYSA-N
3-(4-chlorophenyl)-5-(3,4-difluorophenethoxy)imidazo[1,5-a]pyrazine
Context
Original Sources
Inherited (110 nM)
A New Triazolopyrazine Series for OSM - Series 4
Biological Data
Results of Series 4 Aldehyde Oxidase Assay
Comparisons with Novartis compound:
Similarity of Series 4 Compounds to KAI407
Synonyms
MMV669846
FC1=C(F)C=CC(CCOC2=CN=CC3=NC=C(C4=CC=C(Cl)C=C4)N32)=C1
InChI=1S/C20H14ClF2N3O/c21-15-4-2-14(3-5-15)18-10-25-19-11-24-12-20(26(18)19)27-8-7-13-1-6-16(22)17(23)9-13/h1-6,9-12H,7-8H2
MQHQNFQVEXYAMO-UHFFFAOYSA-N
3-(4-chlorophenyl)-5-(3,4-difluorophenethoxy)imidazo[1,2-a]pyrazine
Context
Series 4
Original Sources
Inherited
A New Triazolopyrazine Series for OSM - Series 4
Biological Data
Much inherited biological data:
Initial Pharmacokinetic and Efficacy Studies on Series 4
Synonyms
MMV639565
FC1=C(F)C=CC(CCOC2=CN=CC3=NN=C(C4=CC=C(Cl)C=C4)N32)=C1
InChI=1S/C19H13ClF2N4O/c20-14-4-2-13(3-5-14)19-25-24-17-10-23-11-18(26(17)19)27-8-7-12-1-6-15(21)16(22)9-12/h1-6,9-11H,7-8H2
PMHUSEXABGDNGS-UHFFFAOYSA-N
3-(4-chlorophenyl)-5-(3,4-difluorophenethoxy)-[1,2,4]triazolo[4,3-a]pyrazine
Original Sources
Biological Data
N/A
Synonyms
TM 55
O=C(NC1=CC(Cl)=CC=C1)C2=CN=CC(N23)=NN=C3C4=CC=C(OC(F)(F)F)C=C4
InChI=1S/C19H11ClF3N5O2/c20-12-2-1-3-13(8-12)25-18(29)15-9-24-10-16-26-27-17(28(15)16)11-4-6-14(7-5-11)30-19(21,22)23/h1-10H,(H,25,29)
KPPYAXXEDYTONY-UHFFFAOYSA-N
N-(3-chlorophenyl)-3-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide
Original Sources
Biological Data
N/A
Synonyms
TM 54
O=C(NC1=CC(Cl)=CC=C1)C2=CN=CC(N23)=NN=C3C4=CC=C(OC)C=C4
InChI=1S/C19H14ClN5O2/c1-27-15-7-5-12(6-8-15)18-24-23-17-11-21-10-16(25(17)18)19(26)22-14-4-2-3-13(20)9-14/h2-11H,1H3,(H,22,26)
PVPGYERJOUVPIJ-UHFFFAOYSA-N
N-(3-chlorophenyl)-3-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide