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16th August 2013 @ 01:12

For original synthesis see here. Resynthesised for characterisation and possible submission to new assay.

Going to start at 4.30pm

AEW 76-1 (50 mg, 0.13 mmol, 1 equiv.) was dissolved partially in toluene (~5 mL) and stirred under a nitrogen atmosphere. Pyridine (~20 μL, 0.25 mmol, 1.9 equiv.) was added, followed by acetic anhydride (~40 μL, 0.4 mmol, 3 equiv.). The mixture was heated to 80 °C and left stirring overnight under nitrogen.

Hazard and Risk Assesment:

See Acetylation of para-trifluoromethyl near neighbour analogue (ZYH 12-1)

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AEW 79-1.png