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26th February 2013 @ 05:51

Synthesis of 2-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole-3-sulfonamido)acetamide with longer time spent stirring with amine.

 

 

Reaction start time: 12:30 PM EST 25/2/13
MD 6-5 (150 mg, 0.51 mmol, 1 equiv) and Phosphorous Pentachloride (105 mg, 0.68 mmol, 1 equiv) were mixed at room temperature in dry diethyl ether (10 mL) for 2 hours under an inert atmosphere. After 2 hours the mixture was filtered and to the filtrate was added pyridine (260 µL, 2.0 mmol, 3.9 equiv.) followed by 2-aminoacetamide (100 mg, 1.3 mmol, 2.5 equiv.). Reaction was left stirring for 3 hours at room temperature. Reaction was concentrated under reduced pressure leaving a brown residue (14 mg).

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