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Historically, the synthesis of pyrimethamine/Daraprim has been done in three steps, with minor variations in the conditions used for each of these transformations.
The literature conditions to accomplish these transformations usually include rough conditions not suited for student-run experiments. Harsh basic conditions(NaOEt in refluxing ethanol, LDA at -78 °C:) are usually used for step 1. Diazomethane has been used for the alkylation in step 2, and step 3 requires access to free guanidine prepared from guanidine hydrochloride and sodium ethoxide. The conditions historically used for step 1 and step 2 will be avoided in this experiment as they include harsh base, and highly toxic and explosive reagents.
As of 2016-09-05, suitable conditions have been developped for reaction 1 but not 2 or 3. See DP-1-1